🏥 USMLE Exam Prep

A 55-year-old patient is intubated and mechanically ventilated for severe acute respiratory distress syndrome (ARDS). Which ventilator strategy is recommended to improve outcomes in ARDS?

A High tidal volume ventilation (10-12 mL/kg predicted body weight).
B Permissive hypercapnia with a target arterial pH of 7.40-7.45.
C Low tidal volume ventilation (4-8 mL/kg predicted body weight) with plateau pressure <30 cm H2O.
D Minimal PEEP to avoid barotrauma and hemodynamic compromise.

✓ Correct Answer: Option C

Lung-protective ventilation with low tidal volumes (4-8 mL/kg predicted body weight) and maintaining plateau pressures below 30 cm H2O is the cornerstone of ARDS management, significantly reducing mortality.

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