A 55-year-old male with no significant past medical history presents for a routine physical exam. He is a former smoker (quit 10 years ago) and has no family history of colon cancer. Which of the following cancer screenings is most appropriate to discuss with him at this visit?

The correct answer to the question "A 55-year-old male with no significant past medical history presents for a routine physical exam. He is a former smoker (quit 10 years ago) and has no family history of colon cancer. Which of the following cancer screenings is most appropriate to discuss with him at this visit?" is Option C: Screening colonoscopy..

The other options — A) Prostate-specific antigen (PSA) screening., B) Low-dose computed tomography (LDCT) for lung cancer., D) Alpha-fetoprotein (AFP) for hepatocellular carcinoma. — are incorrect for this USMLE Exam Prep question. As explained above: Screening colonoscopy is recommended for average-risk individuals starting at age 45-50 until age 75. His age of 55 falls within this recommendation. LDCT is for current smokers or those who quit wit…