A 55-year-old male presents with acute onset severe pain, swelling, and redness in his right great toe for the past 12 hours. He has a history of similar episodes. He takes warfarin for atrial fibrillation. Which of the following is the most appropriate initial treatment for this acute gout flare?

✓ Correct Answer: Option B

Given the patient is on warfarin, NSAIDs like indomethacin are contraindicated due to increased bleeding risk. Colchicine is an appropriate first-line treatment for acute gout flares, especially when started early, and is safe with warfarin. Allopurinol and probenecid are for chronic management.