A 50-year-old male with no family history of colorectal cancer and no alarming symptoms presents for routine screening. Which of the following screening modalities, if chosen and negative, allows for the longest recommended interval before the next screening?

✓ Correct Answer: Option B

Colonoscopy, if negative, provides the longest recommended interval (10 years) before repeat screening compared to annual FIT or stool DNA tests (1-3 years), or flexible sigmoidoscopy (5 years), making it a comprehensive primary option.