🏥 USMLE Exam Prep

A 5-year-old child presents with hypotonia, hyperphagia leading to obesity, intellectual disability, and short stature. Genetic testing reveals a deletion on chromosome 15 inherited from the father. This constellation of symptoms is characteristic of which genetic disorder?

A Angelman Syndrome
B Prader-Willi Syndrome
C Marfan Syndrome
D Down Syndrome

✓ Correct Answer: Option B

Prader-Willi Syndrome is caused by the loss of paternally inherited genes on chromosome 15 (15q11-q13), leading to hypotonia, hyperphagia, obesity, and intellectual disability. Angelman syndrome involves maternal deletion.

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