A 48-year-old woman presents with palpitations, heat intolerance, weight loss despite increased appetite, and tremor. Her thyroid-stimulating hormone (TSH) is <0.01 mIU/L, and free T4 is elevated. Physical examination reveals an enlarged, non-tender thyroid gland with a bruit. Which of the following is the most appropriate initial pharmacological treatment?

The correct answer to the question "A 48-year-old woman presents with palpitations, heat intolerance, weight loss despite increased appetite, and tremor. Her thyroid-stimulating hormone (TSH) is <0.01 mIU/L, and free T4 is elevated. Physical examination reveals an enlarged, non-tender thyroid gland with a bruit. Which of the following is the most appropriate initial pharmacological treatment?" is Option B: Methimazole.

The other options — A) Levothyroxine, C) Iodine-131 therapy, D) Propylthiouracil (PTU) — are incorrect for this USMLE Exam Prep question. As explained above: This patient has Graves' disease (hyperthyroidism). Methimazole is the preferred initial antithyroid medication due to its efficacy and once-daily dosing. PTU is generally reserved for the first trim…