A 45-year-old woman is diagnosed with major depressive disorder. She has no significant medical comorbidities and takes no other medications. Which of the following is considered the first-line pharmacotherapy for this condition?

✓ Correct Answer: Option C

Selective serotonin reuptake inhibitors (SSRIs) are widely considered the first-line pharmacotherapy for major depressive disorder due to their efficacy, favorable side effect profile, and good tolerability.