🏥 USMLE Exam Prep

A 45-year-old female presents for a routine physical exam. On palpation, a 2.5 cm firm, non-tender thyroid nodule is noted. Thyroid stimulating hormone (TSH) level is within normal limits. What is the most appropriate next step in the evaluation of this nodule?

A Prescribe levothyroxine to suppress TSH.
B Perform a radioactive iodine uptake scan.
C Refer for surgical resection of the nodule.
D Perform an ultrasound-guided fine-needle aspiration (FNA) biopsy.

✓ Correct Answer: Option D

For euthyroid thyroid nodules greater than 1 cm, especially those with suspicious ultrasound features or rapid growth, FNA biopsy is the most appropriate next step to assess for malignancy.

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