A 42-year-old female presents with symptoms consistent with uncomplicated cystitis. Urine dipstick shows positive leukocyte esterase and nitrites. She has no known drug allergies. What is the most appropriate empiric oral antibiotic regimen?

✓ Correct Answer: Option C

Trimethoprim-sulfamethoxazole (TMP-SMX) is a first-line empiric antibiotic for uncomplicated cystitis, typically prescribed for a 3-day course. It is effective against common urinary pathogens and helps conserve fluoroquinolones for more complex infections or allergies.