🏥 USMLE Exam Prep

A 40-year-old male presents with acute onset of right great toe pain, swelling, and redness. He denies trauma. He has a history of hypertension controlled with hydrochlorothiazide. Physical exam reveals a warm, tender, erythematous right first metatarsophalangeal joint. Serum uric acid is elevated. Which of the following is the most appropriate initial treatment for his acute gout flare?

A Allopurinol.
B Probenecid.
C Colchicine.
D Febuxostat.

✓ Correct Answer: Option C

For an acute gout flare, treatment aims to reduce inflammation. Colchicine, NSAIDs (if not contraindicated), or corticosteroids are appropriate initial choices. Allopurinol, probenecid, and febuxostat are uric acid-lowering therapies used for long-term management and are typically not started during an acute flare.

💡 Why is C) the correct answer?

The correct answer to the question "A 40-year-old male presents with acute onset of right great toe pain, swelling, and redness. He denies trauma. He has a history of hypertension controlled with hydrochlorothiazide. Physical exam reveals a warm, tender, erythematous right first metatarsophalangeal joint. Serum uric acid is elevated. Which of the following is the most appropriate initial treatment for his acute gout flare?" is Option C: Colchicine..

The other options — A) Allopurinol., B) Probenecid., D) Febuxostat. — are incorrect for this USMLE Exam Prep question. As explained above: For an acute gout flare, treatment aims to reduce inflammation. Colchicine, NSAIDs (if not contraindicated), or corticosteroids are appropriate initial choices. Allopurinol, probenecid, and febuxosta…

📚 About This USMLE Exam Prep Practice Question

This 2-level USMLE Exam Prep question from the Step 3 – Clinical Management topic is part of BrainForge Quiz's free exam preparation library. Each question includes the correct answer and a detailed explanation to help you understand the underlying concept, not just memorize the answer.

How to use this page: Read the question above, consider all four options (A through D), then check the highlighted correct answer and explanation. For active timed practice, start a free USMLE Exam Prep practice test or use flashcards for spaced repetition review.

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