A 4-year-old child presents with recurrent infections, particularly bacterial and fungal, and oculocutaneous albinism. Microscopic examination of neutrophils reveals giant lysosomes. Which of the following is the most likely diagnosis?

The correct answer to the question "A 4-year-old child presents with recurrent infections, particularly bacterial and fungal, and oculocutaneous albinism. Microscopic examination of neutrophils reveals giant lysosomes. Which of the following is the most likely diagnosis?" is Option C: Chediak-Higashi Syndrome.

The other options — A) Wiskott-Aldrich Syndrome, B) X-linked Agammaglobulinemia, D) Severe Combined Immunodeficiency — are incorrect for this USMLE Exam Prep question. As explained above: Chediak-Higashi syndrome is an autosomal recessive disorder characterized by impaired lysosomal trafficking, leading to giant lysosomes in phagocytes. This causes recurrent pyogenic infections, parti…