A 35-year-old woman with a 10-year history of Crohn's disease, currently on mesalamine, presents with severe abdominal pain, bloody diarrhea, and weight loss. Endoscopy reveals continuous inflammation extending from the rectum to the splenic flexure, with multiple pseudopolyps. Histopathology shows crypt abscesses and goblet cell depletion. Which of the following is the most likely diagnosis?
✓ Correct Answer: Option B
The endoscopic findings (continuous inflammation from rectum, pseudopolyps) and histology (crypt abscesses, goblet cell depletion) are classic for ulcerative colitis, not Crohn's disease, which is typically patchy with skip lesions. This suggests a re-evaluation of her initial diagnosis.