🏥 USMLE Exam Prep

A 35-year-old G2P1 female presents to the clinic at 10 weeks gestation for her first prenatal visit. She has a history of major depressive disorder, well-controlled on sertraline 100 mg daily for the past 2 years. She is concerned about continuing her medication during pregnancy. What is the most appropriate recommendation regarding her sertraline regimen?

A Discontinue sertraline immediately to avoid fetal exposure.
B Switch to a different antidepressant with a better safety profile in pregnancy.
C Continue sertraline, discussing the low risk of adverse effects versus the risk of untreated depression.
D Decrease the sertraline dose to the lowest effective dose.

✓ Correct Answer: Option C

Untreated major depression in pregnancy carries significant risks to both mother and fetus. Sertraline is generally considered a first-line antidepressant in pregnancy, with a relatively low risk profile. Discontinuation or switching without compelling reason is often not recommended due to relapse risk.

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