🏥 USMLE Exam Prep

A 30-year-old pregnant woman at 30 weeks gestation presents with persistent right upper quadrant pain, nausea, and vomiting. Laboratory tests reveal elevated liver enzymes (AST 200 U/L, ALT 250 U/L), total bilirubin 3.0 mg/dL, and an alkaline phosphatase of 300 U/L. Ultrasound shows cholelithiasis without signs of cholecystitis or common bile duct dilation. Which of the following is the most appropriate management at this time?

A Immediate cholecystectomy.
B Endoscopic retrograde cholangiopancreatography (ERCP).
C Conservative management with pain control and observation.
D Administration of ursodeoxycholic acid.

✓ Correct Answer: Option C

The patient presents with symptomatic cholelithiasis (biliary colic) without evidence of acute cholecystitis, choledocholithiasis, or cholangitis. During pregnancy, conservative management with pain control and dietary modification is generally preferred unless complications arise. Surgical intervention is usually deferred until postpartum if possible.

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