🏥 USMLE Exam Prep

A 30-year-old male with no significant past medical history presents with a 3-day history of fever, productive cough, and malaise. Chest X-ray reveals a left lower lobe infiltrate. His vital signs are stable, and he has a CURB-65 score of 0. He has no recent antibiotic use. What is the most appropriate empiric oral antibiotic therapy?

A Levofloxacin
B Azithromycin
C Amoxicillin-clavulanate
D Trimethoprim-sulfamethoxazole

✓ Correct Answer: Option B

For outpatient community-acquired pneumonia in otherwise healthy individuals with no recent antibiotic use, a macrolide (e.g., azithromycin) or doxycycline is recommended. Fluoroquinolones are generally reserved for sicker patients or those with comorbidities.

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