A 30-year-old female presents with a 3-month history of migratory polyarthritis, a malar rash that worsens with sun exposure, and generalized fatigue. Laboratory tests show positive antinuclear antibodies (ANA) and anti-dsDNA antibodies. What is the most appropriate initial pharmacotherapy?
✓ Correct Answer: Option B
This patient's presentation and lab findings are highly suggestive of Systemic Lupus Erythematosus (SLE). Hydroxychloroquine is the recommended first-line agent for most patients with SLE, particularly for skin and joint manifestations, and has disease-modifying effects.
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