🏥 USMLE Exam Prep

A 28-year-old woman is found to have a CD4+ T-lymphocyte count of 150 cells/µL. She is HIV-positive and not currently on antiretroviral therapy. Which opportunistic infection prophylaxis should be initiated?

A Valganciclovir for cytomegalovirus (CMV)
B Azithromycin for Mycobacterium avium complex (MAC)
C Trimethoprim-sulfamethoxazole for Pneumocystis jirovecii pneumonia (PCP)
D Fluconazole for cryptococcal meningitis

✓ Correct Answer: Option C

Prophylaxis for Pneumocystis jirovecii pneumonia (PCP) with trimethoprim-sulfamethoxazole is indicated when the CD4 count falls below 200 cells/µL. MAC prophylaxis (azithromycin) is for CD4 < 50 cells/µL.

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