🏥 USMLE Exam Prep

A 28-year-old man presents with a 2-week history of painful vesicular lesions on his penis, dysuria, and bilateral inguinal lymphadenopathy. He reports unprotected sexual contact with a new partner. Tzanck smear shows multinucleated giant cells. What is the most appropriate treatment for this condition?

A Azithromycin
B Ceftriaxone
C Acyclovir
D Doxycycline

✓ Correct Answer: Option C

The clinical presentation (painful vesicular lesions, dysuria, lymphadenopathy, multinucleated giant cells on Tzanck smear) is classic for herpes simplex virus (genital herpes). Acyclovir is the first-line antiviral treatment.

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