A 28-year-old female presents with chronic diarrhea, crampy abdominal pain, and unintentional weight loss for the past 6 months. Colonoscopy reveals transmural inflammation with skip lesions and non-caseating granulomas on biopsy. What is the most likely diagnosis?

✓ Correct Answer: Option C

The presence of transmural inflammation, skip lesions, and non-caseating granulomas on biopsy are classic pathological findings for Crohn's Disease. Ulcerative colitis involves continuous mucosal inflammation, typically without granulomas or skip lesions.