A 24-year-old male returns from a hiking trip in the northeastern United States with a fever, headache, myalgia, and a large, expanding erythematous rash with central clearing on his thigh. He reports recalling a tick bite approximately 10 days ago. What is the most appropriate treatment?
✓ Correct Answer: Option B
The patient's presentation (fever, headache, myalgia, erythema migrans after a tick bite in an endemic area) is classic for early localized Lyme disease. Doxycycline is the first-line treatment for adults and children over 8 years old.